The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunction.

Dean, Paul; Scott, Jon A; Knox, Andrew A; Quitard, Sabine; Watkins, Nicholas J; Kenny, Brendan

Dean, Paul; Scott, Jon A; Knox, Andrew A; Quitard, Sabine; Watkins, Nicholas J; Kenny, Brendan.

Affiliation

Dean P; Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom. p.dean@ncl.ac.uk

PLoS Pathog ; 6(6): e1000961, 2010 Jun 24.

Article in En | MEDLINE | ID: mdl-20585567

Subject(s)

Carrier Proteins/metabolism; Cell Nucleolus/physiology; Enteropathogenic Escherichia coli/pathogenicity; Escherichia coli Infections/pathology; Escherichia coli Proteins/metabolism; Mitochondria/microbiology; Mitochondria/pathology; Amino Acid Sequence; Blotting, Western; Carrier Proteins/genetics; DNA, Bacterial/genetics; Enteropathogenic Escherichia coli/genetics; Enteropathogenic Escherichia coli/metabolism; Escherichia coli Infections/metabolism; Escherichia coli Infections/microbiology; Escherichia coli Proteins/genetics; Fluorescent Antibody Technique; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Mitochondria/metabolism; Molecular Sequence Data; Phosphoproteins/genetics; Phosphoproteins/metabolism; Polymerase Chain Reaction; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Sequence Homology, Amino Acid; Signal Transduction; Nucleolin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carrier Proteins / Cell Nucleolus / Escherichia coli Proteins / Escherichia coli Infections / Enteropathogenic Escherichia coli / Mitochondria Limits: Humans Language: En Journal: PLoS Pathog Year: 2010 Type: Article Affiliation country: United kingdom

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