New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides.

Prugh, J D; Hartman, G D; Mallorga, P J; McKeever, B M; Michelson, S R; Murcko, M A; Schwam, H; Smith, R L; Sondey, J M; Springer, J P

Prugh, J D; Hartman, G D; Mallorga, P J; McKeever, B M; Michelson, S R; Murcko, M A; Schwam, H; Smith, R L; Sondey, J M; Springer, J P.

Affiliation

Prugh JD; Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486.

J Med Chem ; 34(6): 1805-18, 1991 Jun.

Article in En | MEDLINE | ID: mdl-2061922

Subject(s)

Carbonic Anhydrase Inhibitors/pharmacology; Glaucoma/drug therapy; Ocular Hypotension/drug therapy; Sulfonamides/pharmacology; Thiophenes/pharmacology; Animals; Carbonic Anhydrase Inhibitors/chemical synthesis; In Vitro Techniques; Isomerism; Models, Molecular; Rabbits; Sulfonamides/chemical synthesis; Thiophenes/chemical synthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Thiophenes / Carbonic Anhydrase Inhibitors / Ocular Hypotension / Glaucoma Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1991 Type: Article

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