Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.
J Allergy Clin Immunol
; 126(2): 332-7, 337.e1-2, 2010 Aug.
Article
in En
| MEDLINE
| ID: mdl-20621347
ABSTRACT
BACKGROUND:
IL-1 receptor-associated kinase 4 (IRAK-4) is an effector of the Toll-like receptor and IL-1 receptor pathways that plays a critical role in innate immune responses. The role of IRAK-4 in adaptive immune functions in human subjects is incompletely understood.OBJECTIVE:
We sought to evaluate T-cell function in IRAK-4 deficient patients.METHODS:
We compared upregulation of CD25 and CD69 on T cells and production of IL-2, IL-6, and IFN-gamma after stimulation of PBMCs from 4 IRAK-4-deficient patients and healthy control subjects with anti-CD3 and anti-CD28.RESULTS:
Upregulation of CD25 and CD69 on T cells and production of IL-6 and IFN-gamma, but not IL-2, was significantly reduced in IRAK-4-deficient patients.CONCLUSIONS:
IRAK-4-deficient patients have defects in T-cell activation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
Receptors, Antigen, T-Cell
/
T-Lymphocytes
/
Interleukin-1 Receptor-Associated Kinases
/
Genetic Diseases, Inborn
/
Immunologic Deficiency Syndromes
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Language:
En
Journal:
J Allergy Clin Immunol
Year:
2010
Type:
Article
Affiliation country:
United States