Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1ß.

Nicholas, Sally A; Bubnov, Vladimir V; Yasinska, Inna M; Sumbayev, Vadim V

Nicholas, Sally A; Bubnov, Vladimir V; Yasinska, Inna M; Sumbayev, Vadim V.

Affiliation

Nicholas SA; Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.

Cell Mol Life Sci ; 68(1): 151-8, 2011 Jan.

Article in En | MEDLINE | ID: mdl-20632067

Subject(s)

Caspase 1/metabolism; Hypoxia-Inducible Factor 1/physiology; Interleukin-1beta/metabolism; Toll-Like Receptor 7/physiology; Toll-Like Receptor 8/physiology; Xanthine Oxidase/physiology; Allopurinol/pharmacology; Animals; Carrier Proteins/genetics; Carrier Proteins/physiology; Enzyme Activation; Humans; Imidazoles/pharmacology; Ligands; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidation-Reduction; Reactive Oxygen Species/metabolism; Signal Transduction; Toll-Like Receptor 7/agonists; Toll-Like Receptor 7/metabolism; Toll-Like Receptor 8/agonists; Toll-Like Receptor 8/metabolism; Tumor Cells, Cultured; Xanthine Oxidase/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Xanthine Oxidase / Caspase 1 / Hypoxia-Inducible Factor 1 / Toll-Like Receptor 7 / Toll-Like Receptor 8 / Interleukin-1beta Limits: Animals / Humans / Male Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2011 Type: Article Affiliation country: United kingdom

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