Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN.

Chia, Joel Yeong-Chit; Gajewski, Joanna E; Xiao, Yi; Zhu, Hong-Jian; Cheng, Heung-Chin

Chia, Joel Yeong-Chit; Gajewski, Joanna E; Xiao, Yi; Zhu, Hong-Jian; Cheng, Heung-Chin.

Affiliation

Chia JY; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

Biochim Biophys Acta ; 1804(9): 1785-95, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20685300

Subject(s)

PTEN Phosphohydrolase/metabolism; Peptide Fragments/metabolism; Phosphatidylinositol Phosphates/metabolism; Phosphopeptides/metabolism; Tyrosine/metabolism; Catalytic Domain; Humans; Mutagenesis, Site-Directed; Mutation/genetics; PTEN Phosphohydrolase/chemistry; PTEN Phosphohydrolase/genetics; Peptide Fragments/genetics; Phosphopeptides/chemistry; Phosphopeptides/genetics; Phosphorylation; Protein Conformation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Phosphopeptides / Tyrosine / Phosphatidylinositol Phosphates / PTEN Phosphohydrolase Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2010 Type: Article Affiliation country: Australia

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