Five mutations of mitochondrial DNA polymerase-gamma (POLG) are not a prevalent etiology for spontaneous 46,XX primary ovarian insufficiency.

Tong, Zhi-Bin; Sullivan, Shannon D; Lawless, Lindsey M; Vanderhoof, Vien; Zachman, Keith; Nelson, Lawrence M

Tong, Zhi-Bin; Sullivan, Shannon D; Lawless, Lindsey M; Vanderhoof, Vien; Zachman, Keith; Nelson, Lawrence M.

Affiliation

Tong ZB; Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1103, USA.

Fertil Steril ; 94(7): 2932-4, 2010 Dec.

Article in En | MEDLINE | ID: mdl-20701905

Subject(s)

DNA-Directed DNA Polymerase/genetics; Primary Ovarian Insufficiency/genetics; 46, XX Disorders of Sex Development/complications; 46, XX Disorders of Sex Development/genetics; Adolescent; Adult; Cross-Sectional Studies; DNA Polymerase gamma; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Mutation/physiology; Polymorphism, Single Nucleotide/physiology; Primary Ovarian Insufficiency/etiology; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Primary Ovarian Insufficiency / DNA-Directed DNA Polymerase Type of study: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Adult / Female / Humans Language: En Journal: Fertil Steril Year: 2010 Type: Article Affiliation country: United States

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