Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities.

Padhye, Subhash; Ahmad, Aamir; Oswal, Nikhil; Dandawate, Prasad; Rub, Rukhsana A; Deshpande, Jyoti; Swamy, K Venkateswara; Sarkar, Fazlul H

Padhye, Subhash; Ahmad, Aamir; Oswal, Nikhil; Dandawate, Prasad; Rub, Rukhsana A; Deshpande, Jyoti; Swamy, K Venkateswara; Sarkar, Fazlul H.

Affiliation

Padhye S; Department of Pathology, Barbara Ann Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, MI 48201, USA.

Bioorg Med Chem Lett ; 20(19): 5818-21, 2010 Oct 01.

Article in En | MEDLINE | ID: mdl-20729081

Subject(s)

Antineoplastic Agents/chemistry; Antioxidants/chemistry; Chalcones/chemistry; Terpenes/chemistry; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/therapeutic use; Antioxidants/chemical synthesis; Antioxidants/pharmacology; Binding Sites; Cell Line, Tumor; Computer Simulation; Cyclooxygenase 2/chemistry; Cyclooxygenase 2/metabolism; Halogenation; Humans; Pancreatic Neoplasms/drug therapy; Protein Structure, Tertiary; Superoxide Dismutase/metabolism; Terpenes/chemical synthesis; Terpenes/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Terpenes / Chalcones / Antineoplastic Agents / Antioxidants Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States

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