EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic ß-cells.

Wang, Haijuan; Gambosova, Katarina; Cooper, Zachary A; Holloway, Michael P; Kassai, Andrea; Izquierdo, Denisse; Cleveland, Kelly; Boney, Charlotte M; Altura, Rachel A

Wang, Haijuan; Gambosova, Katarina; Cooper, Zachary A; Holloway, Michael P; Kassai, Andrea; Izquierdo, Denisse; Cleveland, Kelly; Boney, Charlotte M; Altura, Rachel A.

Affiliation

Wang H; Department of Pediatrics, Division of Pediatric Hematology-Oncology, Brown University, Providence, RI 02903, USA.

BMC Mol Biol ; 11: 66, 2010 Aug 31.

Article in En | MEDLINE | ID: mdl-20807437

Subject(s)

Epidermal Growth Factor/pharmacology; Extracellular Signal-Regulated MAP Kinases/metabolism; Inhibitor of Apoptosis Proteins/metabolism; Insulin-Secreting Cells/drug effects; Insulin-Secreting Cells/metabolism; Proto-Oncogene Proteins c-raf/metabolism; Repressor Proteins/metabolism; Signal Transduction/physiology; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors/metabolism; Enzyme Inhibitors/pharmacology; Extracellular Signal-Regulated MAP Kinases/genetics; Glucose/metabolism; Humans; Inhibitor of Apoptosis Proteins/genetics; Insulin/metabolism; Insulin-Secreting Cells/cytology; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-raf/genetics; Rats; Repressor Proteins/genetics; Survivin; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Signal Transduction / Proto-Oncogene Proteins c-raf / Extracellular Signal-Regulated MAP Kinases / Epidermal Growth Factor / Insulin-Secreting Cells / Inhibitor of Apoptosis Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: BMC Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2010 Type: Article Affiliation country: United States

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