Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.

Yamaguchi, Tamio; Reif, Gail A; Calvet, James P; Wallace, Darren P

Yamaguchi, Tamio; Reif, Gail A; Calvet, James P; Wallace, Darren P.

Am J Physiol Renal Physiol ; 299(5): F944-51, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20810616

Subject(s)

Benzenesulfonates/therapeutic use; Cyclic AMP-Dependent Protein Kinases/metabolism; Epithelial Cells/drug effects; Epithelial Cells/enzymology; Polycystic Kidney, Autosomal Dominant/enzymology; Polycystic Kidney, Autosomal Dominant/pathology; Protein Kinase Inhibitors/therapeutic use; Pyridines/therapeutic use; Blotting, Western; Cell Proliferation/drug effects; Cells, Cultured; Enzyme Activation/drug effects; Epidermal Growth Factor/pharmacology; Humans; Mitogen-Activated Protein Kinases/metabolism; Niacinamide/analogs & derivatives; Phenylurea Compounds; Proto-Oncogene Proteins B-raf/metabolism; Proto-Oncogene Proteins c-raf/metabolism; Signal Transduction/drug effects; Sorafenib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Benzenesulfonates / Polycystic Kidney, Autosomal Dominant / Cyclic AMP-Dependent Protein Kinases / Protein Kinase Inhibitors / Epithelial Cells Limits: Humans Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2010 Type: Article

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