The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation.
Science
; 329(5996): 1205-10, 2010 Sep 03.
Article
in En
| MEDLINE
| ID: mdl-20813954
ABSTRACT
Gammadelta T cells present in epithelial tissues provide a crucial first line of defense against environmental insults, including infection, trauma, and malignancy, yet the molecular events surrounding their activation remain poorly defined. Here we identify an epithelial gammadelta T cell-specific costimulatory molecule, junctional adhesion molecule-like protein (JAML). Binding of JAML to its ligand Coxsackie and adenovirus receptor (CAR) provides costimulation leading to cellular proliferation and cytokine and growth factor production. Inhibition of JAML costimulation leads to diminished gammadelta T cell activation and delayed wound closure akin to that seen in the absence of gammadelta T cells. Our results identify JAML as a crucial component of epithelial gammadelta T cell biology and have broader implications for CAR and JAML in tissue homeostasis and repair.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Virus
/
Lymphocyte Activation
/
Cell Adhesion Molecules
/
T-Lymphocyte Subsets
/
Receptors, Antigen, T-Cell, gamma-delta
/
Epidermis
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Science
Year:
2010
Type:
Article
Affiliation country:
United States