Treatment with sildenafil prevents impairment of learning in rats born to pre-eclamptic mothers.

Cauli, O; Herraiz, S; Pellicer, B; Pellicer, A; Felipo, V

Cauli, O; Herraiz, S; Pellicer, B; Pellicer, A; Felipo, V.

Affiliation

Cauli O; Laboratory of Neurobiology, Centro de Investigación Principe Felipe, Valencia, Spain.

Neuroscience ; 171(2): 506-12, 2010 Dec 01.

Article in En | MEDLINE | ID: mdl-20832451

Subject(s)

Learning/drug effects; Phosphodiesterase Inhibitors/pharmacology; Piperazines/pharmacology; Pre-Eclampsia/physiopathology; Prenatal Exposure Delayed Effects/drug therapy; Sulfones/pharmacology; Animals; Blood Pressure/drug effects; Cerebellum/metabolism; Cyclic GMP/physiology; Discrimination Learning/drug effects; Female; Glutamic Acid/physiology; Maze Learning/drug effects; Microdialysis; Motor Activity/drug effects; NG-Nitroarginine Methyl Ester; Nitric Oxide/physiology; Nitric Oxide Synthase/antagonists & inhibitors; Phosphodiesterase Inhibitors/therapeutic use; Piperazines/therapeutic use; Pre-Eclampsia/chemically induced; Pre-Eclampsia/drug therapy; Pregnancy; Prenatal Exposure Delayed Effects/prevention & control; Prenatal Exposure Delayed Effects/psychology; Purines/pharmacology; Purines/therapeutic use; Rats; Sildenafil Citrate; Sulfones/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Piperazines / Pre-Eclampsia / Prenatal Exposure Delayed Effects / Sulfones / Learning Limits: Animals / Pregnancy Language: En Journal: Neuroscience Year: 2010 Type: Article Affiliation country: Spain

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