Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027.

Chen, Xiaolei; Guo, Zu-Feng; Lai, Pok Man; Sze, Kong Hung; Guo, Zhihong

Chen, Xiaolei; Guo, Zu-Feng; Lai, Pok Man; Sze, Kong Hung; Guo, Zhihong.

Affiliation

Chen X; Department of Chemistry, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.

Angew Chem Int Ed Engl ; 49(43): 7926-8, 2010 Oct 18.

Article in En | MEDLINE | ID: mdl-20848627

Subject(s)

Aminoglycosides/metabolism; Antibiotics, Antineoplastic/metabolism; Bacterial Proteins/metabolism; Enediynes/metabolism; Polyketide Synthases/metabolism; Bacteria/enzymology; Bacterial Proteins/genetics; Escherichia coli/genetics; Gene Expression; Polyketide Synthases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Polyketide Synthases / Enediynes / Aminoglycosides / Antibiotics, Antineoplastic Type of study: Diagnostic_studies Language: En Journal: Angew Chem Int Ed Engl Year: 2010 Type: Article Affiliation country: China

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