Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.

Hassane, Duane C; Sen, Siddhartha; Minhajuddin, Mohammad; Rossi, Randall M; Corbett, Cheryl A; Balys, Marlene; Wei, Liping; Crooks, Peter A; Guzman, Monica L; Jordan, Craig T

Hassane, Duane C; Sen, Siddhartha; Minhajuddin, Mohammad; Rossi, Randall M; Corbett, Cheryl A; Balys, Marlene; Wei, Liping; Crooks, Peter A; Guzman, Monica L; Jordan, Craig T.

Affiliation

Hassane DC; Department of Pathology and Laboratory Medicine, Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10021, USA. dhassane@med.cornell.edu

Blood ; 116(26): 5983-90, 2010 Dec 23.

Article in En | MEDLINE | ID: mdl-20889920

Subject(s)

Enzyme Inhibitors/pharmacology; Gene Expression Profiling; Leukemia, Myeloid, Acute/drug therapy; Leukemia, Myeloid, Acute/genetics; Phosphatidylinositol 3-Kinases/metabolism; Sesquiterpenes/pharmacology; TOR Serine-Threonine Kinases/metabolism; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Blotting, Western; Bone Marrow/drug effects; Cell Proliferation/drug effects; Cells, Cultured; Drug Synergism; Flow Cytometry; Humans; Leukemia, Myeloid, Acute/pathology; Mice; Mice, Inbred NOD; Mice, SCID; Oligonucleotide Array Sequence Analysis; RNA, Messenger/genetics; Reverse Transcriptase Polymerase Chain Reaction; Sirolimus/analogs & derivatives; Sirolimus/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Leukemia, Myeloid, Acute / Phosphatidylinositol 3-Kinases / Gene Expression Profiling / Enzyme Inhibitors / TOR Serine-Threonine Kinases Type of study: Diagnostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Blood Year: 2010 Type: Article Affiliation country: United States

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