Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy.

Sharp, Paul S; Bye-a-Jee, Hema; Wells, Dominic J

Sharp, Paul S; Bye-a-Jee, Hema; Wells, Dominic J.

Affiliation

Sharp PS; Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London, UK.

Mol Ther ; 19(1): 165-71, 2011 Jan.

Article in En | MEDLINE | ID: mdl-20924363

Subject(s)

Dystrophin/biosynthesis; Morpholines/pharmacology; Muscle Strength/physiology; Muscular Dystrophy, Duchenne/physiopathology; Muscular Dystrophy, Duchenne/therapy; Oligonucleotides, Antisense/pharmacology; Animals; Dystrophin/genetics; Dystrophin/metabolism; Exons; Female; Genetic Therapy/methods; Mice; Mice, Inbred mdx; Models, Animal; Morpholines/metabolism; Morpholinos; Muscle Contraction; Muscle Fibers, Skeletal/metabolism; Muscle Strength/drug effects; Muscle Strength/genetics; Muscular Dystrophy, Duchenne/genetics; Muscular Dystrophy, Duchenne/metabolism; Oligonucleotides, Antisense/genetics; Oligonucleotides, Antisense/metabolism; Open Reading Frames; RNA, Messenger/biosynthesis; RNA, Messenger/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morpholines / Dystrophin / Oligonucleotides, Antisense / Muscular Dystrophy, Duchenne / Muscle Strength Type of study: Prognostic_studies Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2011 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google