Distinct molecular mechanisms responsible for bortezomib-induced death of therapy-resistant versus -sensitive B-NHL cells.

Olejniczak, Scott H; Blickwedehl, Jennifer; Belicha-Villanueva, Alan; Bangia, Naveen; Riaz, Wasif; Mavis, Cory; Clements, James L; Gibbs, John; Hernandez-Ilizaliturri, Francisco J; Czuczman, Myron S

Olejniczak, Scott H; Blickwedehl, Jennifer; Belicha-Villanueva, Alan; Bangia, Naveen; Riaz, Wasif; Mavis, Cory; Clements, James L; Gibbs, John; Hernandez-Ilizaliturri, Francisco J; Czuczman, Myron S.

Affiliation

Olejniczak SH; Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.

Blood ; 116(25): 5605-14, 2010 Dec 16.

Article in En | MEDLINE | ID: mdl-20930068

Subject(s)

Antineoplastic Agents/therapeutic use; Boronic Acids/therapeutic use; Drug Resistance, Neoplasm; Lymphoma, B-Cell/drug therapy; Lymphoma, B-Cell/pathology; Proto-Oncogene Proteins c-bcl-2/metabolism; Pyrazines/therapeutic use; Blotting, Western; Bortezomib; Caspases/metabolism; Enzyme Activation/drug effects; Humans; Immunoprecipitation; Lymphoma, B-Cell/metabolism; Prognosis; Tumor Cells, Cultured; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Boronic Acids / Lymphoma, B-Cell / Drug Resistance, Neoplasm / Proto-Oncogene Proteins c-bcl-2 / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Blood Year: 2010 Type: Article Affiliation country: United States

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