Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids as ß-lactamase inhibitors.

Eidam, Oliv; Romagnoli, Chiara; Caselli, Emilia; Babaoglu, Kerim; Pohlhaus, Denise Teotico; Karpiak, Joel; Bonnet, Richard; Shoichet, Brian K; Prati, Fabio

Eidam, Oliv; Romagnoli, Chiara; Caselli, Emilia; Babaoglu, Kerim; Pohlhaus, Denise Teotico; Karpiak, Joel; Bonnet, Richard; Shoichet, Brian K; Prati, Fabio.

Affiliation

Eidam O; Department of Pharmaceutical Chemistry, Byers Hall, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, United States.

J Med Chem ; 53(21): 7852-63, 2010 Nov 11.

Article in En | MEDLINE | ID: mdl-20945905

Subject(s)

Anti-Bacterial Agents/chemical synthesis; Boronic Acids/chemical synthesis; Sulfonamides/chemical synthesis; beta-Lactamase Inhibitors; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Boronic Acids/chemistry; Boronic Acids/pharmacology; Crystallography, X-Ray; Disk Diffusion Antimicrobial Tests; Drug Resistance, Bacterial; Models, Molecular; Molecular Structure; Protein Binding; Stereoisomerism; Structure-Activity Relationship; Sulfonamides/chemistry; Sulfonamides/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Boronic Acids / Beta-Lactamase Inhibitors / Anti-Bacterial Agents Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Type: Article Affiliation country: United States

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