The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils.

Boussetta, Tarek; Gougerot-Pocidalo, Marie-Anne; Hayem, Gilles; Ciappelloni, Silvia; Raad, Houssam; Arabi Derkawi, Riad; Bournier, Odile; Kroviarski, Yolande; Zhou, Xiao Zhen; Malter, James S; Lu, Ping K; Bartegi, Aghleb; Dang, Pham My-Chan; El-Benna, Jamel

Boussetta, Tarek; Gougerot-Pocidalo, Marie-Anne; Hayem, Gilles; Ciappelloni, Silvia; Raad, Houssam; Arabi Derkawi, Riad; Bournier, Odile; Kroviarski, Yolande; Zhou, Xiao Zhen; Malter, James S; Lu, Ping K; Bartegi, Aghleb; Dang, Pham My-Chan; El-Benna, Jamel.

Affiliation

Boussetta T; Inserm U773, Paris, France.

Blood ; 116(26): 5795-802, 2010 Dec 23.

Article in En | MEDLINE | ID: mdl-20956805

Subject(s)

NADPH Oxidases/metabolism; Neutrophils/drug effects; Peptidylprolyl Isomerase/metabolism; Tumor Necrosis Factor-alpha/pharmacology; Blotting, Western; Cell Membrane/metabolism; Cytosol/metabolism; Humans; N-Formylmethionine Leucyl-Phenylalanine/pharmacology; NADPH Oxidases/chemistry; NIMA-Interacting Peptidylprolyl Isomerase; Naphthoquinones/pharmacology; Neutrophils/enzymology; Phosphorylation; Protein Transport; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / NADPH Oxidases / Peptidylprolyl Isomerase / Neutrophils Limits: Humans Language: En Journal: Blood Year: 2010 Type: Article Affiliation country: France

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