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Indazole derivatives as novel bradykinin B1 receptor antagonists.
Bodmer-Narkevitch, Vera; Anthony, Neville J; Cofre, Victoria; Jolly, Samson M; Murphy, Kathy L; Ransom, Richard W; Reiss, Duane R; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J; Bock, Mark G; Kuduk, Scott D.
Affiliation
  • Bodmer-Narkevitch V; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. vbodmer@mac.com
Bioorg Med Chem Lett ; 20(23): 7011-4, 2010 Dec 01.
Article in En | MEDLINE | ID: mdl-20971001
ABSTRACT
A new class of indazole-derived bradykinin B(1) antagonists and their structure-activity relationships (SAR) is reported. A number of compounds were found to have low-nanomolar affinity for the human B(1) receptor and possess acceptable P-gp and pharmacokinetics properties.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bradykinin B1 Receptor Antagonists / Indazoles Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bradykinin B1 Receptor Antagonists / Indazoles Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States