Hypertrophic osteoarthropathy in intestinal transplant recipients.
J Pediatr Surg
; 45(11): e19-22, 2010 Nov.
Article
in En
| MEDLINE
| ID: mdl-21034923
ABSTRACT
We report 3 patients with periosteal new bone formation consistent with hypertrophic osteoarthropathy (HOA), in the context of intestinal allograft rejection. Patient 1 developed thick periosteal new bone formation of the right arm during a prolonged episode of intestinal acute cellular rejection (ACR) 2 months posttransplant. Patient 2 developed ankle pain and swelling during an episode of severe ACR. Plain films showed periosteal new bone formation of the left ankle. In patient 3, the right wrist became swollen during an episode of moderate ACR, whereas plain films demonstrated mild periosteal reaction. Patients 2 and 3 had resolution of their symptoms once the ACR resolved with treatment. This is the first case series of HOA occurring in association with intestinal ACR. We speculate that an immune-mediated process is responsible for the bone disease. Further inquiry will help establish if HOA is related to transplant status, intestinal inflammation, or allograft rejection in general.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoarthropathy, Secondary Hypertrophic
/
Organ Transplantation
/
Graft Rejection
/
Intestine, Small
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
J Pediatr Surg
Year:
2010
Type:
Article
Affiliation country:
United States