Activated inositol 1,4,5-trisphosphate receptors are modified by homogeneous Lys-48- and Lys-63-linked ubiquitin chains, but only Lys-48-linked chains are required for degradation.

Sliter, Danielle A; Aguiar, Mike; Gygi, Steven P; Wojcikiewicz, Richard J H

Sliter, Danielle A; Aguiar, Mike; Gygi, Steven P; Wojcikiewicz, Richard J H.

Affiliation

Sliter DA; Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA.

J Biol Chem ; 286(2): 1074-82, 2011 Jan 14.

Article in En | MEDLINE | ID: mdl-21071436

Subject(s)

Calcium Channels/metabolism; Inositol 1,4,5-Trisphosphate Receptors/metabolism; Receptors, Cytoplasmic and Nuclear/metabolism; Ubiquitin/metabolism; Amino Acid Sequence; Animals; Calcium Channels/chemistry; Cell Line, Tumor; Fibroblasts/cytology; Humans; Inositol 1,4,5-Trisphosphate Receptors/chemistry; Lysine/metabolism; Mice; Molecular Sequence Data; Neuroblastoma; Pancreatic Neoplasms; Pituitary Gland/cytology; Proteasome Endopeptidase Complex/metabolism; Protein Structure, Tertiary; Rats; Receptors, Cytoplasmic and Nuclear/chemistry; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channels / Receptors, Cytoplasmic and Nuclear / Ubiquitin / Inositol 1,4,5-Trisphosphate Receptors Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: United States

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