A genome-wide Drosophila screen for heat nociception identifies &#945;2Î´3 as an evolutionarily conserved pain gene.

Neely, G Gregory; Hess, Andreas; Costigan, Michael; Keene, Alex C; Goulas, Spyros; Langeslag, Michiel; Griffin, Robert S; Belfer, Inna; Dai, Feng; Smith, Shad B; Diatchenko, Luda; Gupta, Vaijayanti; Xia, Cui-Ping; Amann, Sabina; Kreitz, Silke; Heindl-Erdmann, Cornelia; Wolz, Susanne; Ly, Cindy V; Arora, Suchir; Sarangi, Rinku; Dan, Debasis; Novatchkova, Maria; Rosenzweig, Mark; Gibson, Dustin G; Truong, Darwin; Schramek, Daniel; Zoranovic, Tamara; Cronin, Shane J F; Angjeli, Belinda; Brune, Kay; Dietzl, Georg; Maixner, William; Meixner, Arabella; Thomas, Winston; Pospisilik, J Andrew; Alenius, Mattias; Kress, Michaela; Subramaniam, Sai; Garrity, Paul A; Bellen, Hugo J; Woolf, Clifford J; Penninger, Josef M

A genome-wide Drosophila screen for heat nociception identifies α2Î´3 as an evolutionarily conserved pain gene.

Neely, G Gregory; Hess, Andreas; Costigan, Michael; Keene, Alex C; Goulas, Spyros; Langeslag, Michiel; Griffin, Robert S; Belfer, Inna; Dai, Feng; Smith, Shad B; Diatchenko, Luda; Gupta, Vaijayanti; Xia, Cui-Ping; Amann, Sabina; Kreitz, Silke; Heindl-Erdmann, Cornelia; Wolz, Susanne; Ly, Cindy V; Arora, Suchir; Sarangi, Rinku; Dan, Debasis; Novatchkova, Maria; Rosenzweig, Mark; Gibson, Dustin G; Truong, Darwin; Schramek, Daniel; Zoranovic, Tamara; Cronin, Shane J F; Angjeli, Belinda; Brune, Kay; Dietzl, Georg; Maixner, William; Meixner, Arabella; Thomas, Winston; Pospisilik, J Andrew; Alenius, Mattias; Kress, Michaela; Subramaniam, Sai; Garrity, Paul A; Bellen, Hugo J; Woolf, Clifford J; Penninger, Josef M.

Affiliation

Neely GG; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr Gasse 3-5, A-1030 Vienna, Austria.

Cell ; 143(4): 628-38, 2010 Nov 12.

Article in En | MEDLINE | ID: mdl-21074052

Subject(s)

Calcium Channels/genetics; Drosophila Proteins/genetics; Drosophila/genetics; Pain/genetics; Adult; Animals; Back Pain/genetics; Calcium Channels/metabolism; Drosophila Proteins/metabolism; Gene Knockdown Techniques; Genome-Wide Association Study; Hot Temperature; Humans; Mice; Polymorphism, Single Nucleotide; RNA Interference

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Calcium Channels / Drosophila Proteins / Drosophila Limits: Adult / Animals / Humans Language: En Journal: Cell Year: 2010 Type: Article Affiliation country: Austria

Fulltext

XML

PubMed Links

Search on Google