Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R.

Wilhelm, Konrad; Ganesan, Jayanthi; Müller, Tobias; Dürr, Christoph; Grimm, Melanie; Beilhack, Andreas; Krempl, Christine D; Sorichter, Stephan; Gerlach, Ulrike V; Jüttner, Eva; Zerweck, Alf; Gärtner, Frank; Pellegatti, Patrizia; Di Virgilio, Francesco; Ferrari, Davide; Kambham, Neeraja; Fisch, Paul; Finke, Jürgen; Idzko, Marco; Zeiser, Robert

Wilhelm, Konrad; Ganesan, Jayanthi; Müller, Tobias; Dürr, Christoph; Grimm, Melanie; Beilhack, Andreas; Krempl, Christine D; Sorichter, Stephan; Gerlach, Ulrike V; Jüttner, Eva; Zerweck, Alf; Gärtner, Frank; Pellegatti, Patrizia; Di Virgilio, Francesco; Ferrari, Davide; Kambham, Neeraja; Fisch, Paul; Finke, Jürgen; Idzko, Marco; Zeiser, Robert.

Affiliation

Wilhelm K; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany.

Nat Med ; 16(12): 1434-8, 2010 Dec.

Article in En | MEDLINE | ID: mdl-21102458

Subject(s)

Adenosine Triphosphate/metabolism; Extracellular Space/metabolism; Graft vs Host Disease/metabolism; Receptors, Purinergic P2X7/metabolism; Animals; Antigen-Presenting Cells/metabolism; Ascites/metabolism; Ascitic Fluid/metabolism; B7-1 Antigen/metabolism; B7-2 Antigen/metabolism; Bone Marrow Transplantation; Cytokines/immunology; Flow Cytometry; Gastrointestinal Tract/metabolism; Humans; Interferon-gamma/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Phosphorylation; Receptors, Purinergic P2X7/genetics; STAT1 Transcription Factor/metabolism; T-Lymphocytes, Regulatory/immunology; Whole-Body Irradiation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Triphosphate / Extracellular Space / Receptors, Purinergic P2X7 / Graft vs Host Disease Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2010 Type: Article Affiliation country: Germany

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