Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome.

Romay-Penabad, Zurina; Aguilar-Valenzuela, Renan; Urbanus, Rolf T; Derksen, Ronald H W M; Pennings, Maarten T T; Papalardo, Elizabeth; Shilagard, Tuya; Vargas, Gracie; Hwang, Yong; de Groot, Philip G; Pierangeli, Silvia S

Romay-Penabad, Zurina; Aguilar-Valenzuela, Renan; Urbanus, Rolf T; Derksen, Ronald H W M; Pennings, Maarten T T; Papalardo, Elizabeth; Shilagard, Tuya; Vargas, Gracie; Hwang, Yong; de Groot, Philip G; Pierangeli, Silvia S.

Affiliation

Romay-Penabad Z; Department of Internal Medicine, Division of Rheumatology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0883, USA.

Blood ; 117(4): 1408-14, 2011 Jan 27.

Article in En | MEDLINE | ID: mdl-21119114

Subject(s)

Antiphospholipid Syndrome/genetics; LDL-Receptor Related Proteins/physiology; Thrombosis/genetics; Animals; Antibodies, Antiphospholipid/adverse effects; Antibodies, Antiphospholipid/metabolism; Antibodies, Antiphospholipid/pharmacology; Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal/pharmacology; Antibodies, Phospho-Specific/administration & dosage; Antibodies, Phospho-Specific/adverse effects; Antibodies, Phospho-Specific/pharmacology; Antiphospholipid Syndrome/complications; Antiphospholipid Syndrome/pathology; Antiphospholipid Syndrome/prevention & control; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Immunoglobulin G/administration & dosage; Immunoglobulin G/adverse effects; Immunoglobulin G/pharmacology; LDL-Receptor Related Proteins/genetics; LDL-Receptor Related Proteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Thrombosis/etiology; Thrombosis/pathology; beta 2-Glycoprotein I/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Antiphospholipid Syndrome / LDL-Receptor Related Proteins Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Middle aged Language: En Journal: Blood Year: 2011 Type: Article Affiliation country: United States

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