Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers.

Choi, Yeon-hee; Baek, Du Jong; Seo, Seon Hee; Lee, Jae Kyun; Pae, Ae Nim; Cho, Yong Seo; Min, Sun-Joon

Choi, Yeon-hee; Baek, Du Jong; Seo, Seon Hee; Lee, Jae Kyun; Pae, Ae Nim; Cho, Yong Seo; Min, Sun-Joon.

Affiliation

Choi YH; Life/Health Division, Korea Institute of Science and Technology, PO Box 131, Cheongyang, Seoul 130-650, Republic of Korea.

Bioorg Med Chem Lett ; 21(1): 215-9, 2011 Jan 01.

Article in En | MEDLINE | ID: mdl-21126876

Subject(s)

Benzhydryl Compounds/chemical synthesis; Calcium Channel Blockers/chemical synthesis; Calcium Channels, T-Type/chemistry; Piperazines/chemistry; Benzhydryl Compounds/chemistry; Benzhydryl Compounds/pharmacology; Calcium Channel Blockers/chemistry; Calcium Channel Blockers/pharmacology; Calcium Channels, T-Type/metabolism; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors; Ether-A-Go-Go Potassium Channels/metabolism; High-Throughput Screening Assays; Humans; Piperazines/chemical synthesis; Piperazines/pharmacology; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Benzhydryl Compounds / Calcium Channel Blockers / Calcium Channels, T-Type Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article

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