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Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators.
Ward, Simon E; Harries, Mark; Aldegheri, Laura; Austin, Nigel E; Ballantine, Stuart; Ballini, Elisa; Bradley, Daniel M; Bax, Benjamin D; Clarke, Brian P; Harris, Andrew J; Harrison, Stephen A; Melarange, Rosemary A; Mookherjee, Claudette; Mosley, Julie; Dal Negro, Gianni; Oliosi, Beatrice; Smith, Kathrine J; Thewlis, Kevin M; Woollard, Patrick M; Yusaf, Shahnaz P.
Affiliation
  • Ward SE; School of Life Sciences, University of Sussex, Brighton, United Kingdom. simon.ward@sussex.ac.uk
J Med Chem ; 54(1): 78-94, 2011 Jan 13.
Article in En | MEDLINE | ID: mdl-21128618
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, AMPA / Indazoles Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, AMPA / Indazoles Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: United kingdom