In vitro and in vivo evaluation of native glucagon and glucagon analog (MAR-D28) during aging: lack of cytotoxicity and preservation of hyperglycemic effect.

Ward, W Kenneth; Massoud, Ryan G; Szybala, Cory J; Engle, Julia M; El Youssef, Joseph; Carroll, Julie M; Roberts, Charles T; DiMarchi, Richard D

Ward, W Kenneth; Massoud, Ryan G; Szybala, Cory J; Engle, Julia M; El Youssef, Joseph; Carroll, Julie M; Roberts, Charles T; DiMarchi, Richard D.

Affiliation

Ward WK; Legacy Health System (Research), Portland, Oregon 97232, USA. wardk@ohsu.edu

J Diabetes Sci Technol ; 4(6): 1311-21, 2010 Nov 01.

Article in En | MEDLINE | ID: mdl-21129325

Subject(s)

Blood Glucose/drug effects; Fibroblasts/drug effects; Glucagon/pharmacology; Amyloid/chemistry; Animals; Blood Glucose/metabolism; Buffers; Cell Survival/drug effects; Chemistry, Pharmaceutical; Chromatography, Gel; Dose-Response Relationship, Drug; Drug Stability; Drug Storage; Glucagon/administration & dosage; Glucagon/analogs & derivatives; Glucagon/chemistry; Glucagon/toxicity; Hydrogen-Ion Concentration; Injections, Subcutaneous; Mice; NIH 3T3 Cells; Octreotide/pharmacology; Osmolar Concentration; Swine; Time Factors

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Glucose / Glucagon / Fibroblasts Limits: Animals Language: En Journal: J Diabetes Sci Technol Journal subject: ENDOCRINOLOGIA Year: 2010 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google