Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis.

Novgorodov, Sergei A; Chudakova, Daria A; Wheeler, Brian W; Bielawski, Jacek; Kindy, Mark S; Obeid, Lina M; Gudz, Tatyana I

Novgorodov, Sergei A; Chudakova, Daria A; Wheeler, Brian W; Bielawski, Jacek; Kindy, Mark S; Obeid, Lina M; Gudz, Tatyana I.

Affiliation

Novgorodov SA; Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29401, USA.

J Biol Chem ; 286(6): 4644-58, 2011 Feb 11.

Article in En | MEDLINE | ID: mdl-21148554

Subject(s)

Apoptosis/physiology; Brain/enzymology; Calcium/metabolism; Mitochondria/enzymology; Mitochondrial Proteins/metabolism; Nerve Tissue Proteins/metabolism; Oligodendroglia/enzymology; Sphingosine N-Acyltransferase/metabolism; Stem Cells/enzymology; Animals; Brain/cytology; Brain/growth & development; Calpain/genetics; Calpain/metabolism; Cells, Cultured; Female; Gene Knockdown Techniques; Homeostasis/physiology; Mitochondria/genetics; Mitochondrial Proteins/genetics; Nerve Tissue Proteins/genetics; Oligodendroglia/cytology; Rats; Rats, Sprague-Dawley; Sphingosine N-Acyltransferase/genetics; Stem Cells/cytology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Brain / Oligodendroglia / Calcium / Apoptosis / Mitochondrial Proteins / Sphingosine N-Acyltransferase / Mitochondria / Nerve Tissue Proteins Limits: Animals Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: United States

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