Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.

Newton, Ryan H; Leverrier, Sabrina; Srikanth, Sonal; Gwack, Yousang; Cahalan, Michael D; Walsh, Craig M

Newton, Ryan H; Leverrier, Sabrina; Srikanth, Sonal; Gwack, Yousang; Cahalan, Michael D; Walsh, Craig M.

Affiliation

Newton RH; Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USA.

J Immunol ; 186(2): 940-50, 2011 Jan 15.

Article in En | MEDLINE | ID: mdl-21148796

Subject(s)

Apoptosis Regulatory Proteins/metabolism; Calcium Signaling/immunology; Mitochondria/immunology; Mitochondria/metabolism; Protein Kinase C/physiology; Protein Serine-Threonine Kinases/metabolism; Reactive Oxygen Species/metabolism; Receptors, Antigen, T-Cell/physiology; Animals; Apoptosis Regulatory Proteins/deficiency; Apoptosis Regulatory Proteins/genetics; Calcium Signaling/genetics; Clone Cells; Enzyme Activation/genetics; Enzyme Activation/immunology; Homeostasis/genetics; Homeostasis/immunology; Humans; Jurkat Cells; Lymphocyte Activation/genetics; Lymphocyte Activation/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Protein Serine-Threonine Kinases/deficiency; Protein Serine-Threonine Kinases/genetics; T-Lymphocytes/enzymology; T-Lymphocytes/immunology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Receptors, Antigen, T-Cell / Reactive Oxygen Species / Protein Serine-Threonine Kinases / Calcium Signaling / Apoptosis Regulatory Proteins / Mitochondria Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2011 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google