Structure based evolution of a novel series of positive modulators of the AMPA receptor.

Jamieson, Craig; Maclean, John K F; Brown, Christopher I; Campbell, Robert A; Gillen, Kevin J; Gillespie, Jonathan; Kazemier, Bert; Kiczun, Michael; Lamont, Yvonne; Lyons, Amanda J; Moir, Elizabeth M; Morrow, John A; Pantling, John; Rankovic, Zoran; Smith, Lynn

Jamieson, Craig; Maclean, John K F; Brown, Christopher I; Campbell, Robert A; Gillen, Kevin J; Gillespie, Jonathan; Kazemier, Bert; Kiczun, Michael; Lamont, Yvonne; Lyons, Amanda J; Moir, Elizabeth M; Morrow, John A; Pantling, John; Rankovic, Zoran; Smith, Lynn.

Affiliation

Jamieson C; Merck Research Laboratories, MSD, Newhouse, Motherwell, Lanarkshire ML1 5SH, UK. craig.jamieson@strath.ac.uk

Bioorg Med Chem Lett ; 21(2): 805-11, 2011 Jan 15.

Article in En | MEDLINE | ID: mdl-21190850

Subject(s)

Drug Design; Indans/chemistry; Indans/pharmacology; Receptors, AMPA/metabolism; Sulfonamides/chemistry; Sulfonamides/pharmacology; Allosteric Regulation; Animals; Cell Line; Crystallography, X-Ray; Humans; Indans/metabolism; Indans/pharmacokinetics; Microsomes, Liver/metabolism; Models, Molecular; Nervous System Diseases/drug therapy; Nervous System Diseases/metabolism; Pyrazoles/chemistry; Pyrazoles/metabolism; Pyrazoles/pharmacokinetics; Pyrazoles/pharmacology; Rats; Rats, Wistar; Structure-Activity Relationship; Sulfonamides/metabolism; Sulfonamides/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Drug Design / Receptors, AMPA / Indans Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: United kingdom

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