Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.

Scott, Latanya M; Chen, Liwei; Daniel, Kenyon G; Brooks, Wesley H; Guida, Wayne C; Lawrence, Harshani R; Sebti, Said M; Lawrence, Nicholas J; Wu, Jie

Scott, Latanya M; Chen, Liwei; Daniel, Kenyon G; Brooks, Wesley H; Guida, Wayne C; Lawrence, Harshani R; Sebti, Said M; Lawrence, Nicholas J; Wu, Jie.

Affiliation

Scott LM; Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Bioorg Med Chem Lett ; 21(2): 730-3, 2011 Jan 15.

Article in En | MEDLINE | ID: mdl-21193311

Subject(s)

Antineoplastic Agents, Hormonal/chemistry; Antineoplastic Agents, Hormonal/pharmacology; Estramustine/analogs & derivatives; Estramustine/pharmacology; Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism; Humans; Models, Molecular; Neoplasms/drug therapy; Neoplasms/enzymology; Protein Tyrosine Phosphatase, Non-Receptor Type 11/chemistry; Structure-Activity Relationship; Triterpenes/chemistry; Triterpenes/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Agents, Hormonal / Estramustine / Protein Tyrosine Phosphatase, Non-Receptor Type 11 Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: United States

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