Chemical synthesis, characterisation and biological evaluation of furanic-estradiol derivatives as inhibitors of 17ß-hydroxysteroid dehydrogenase type 1.

Farhane, Siham; Laplante, Yannick; Poirier, Donald

Farhane, Siham; Laplante, Yannick; Poirier, Donald.

Affiliation

Farhane S; Laboratory of Medicinal Chemistry, CHUQ (CHUL)-Research Center, 2705, Laurier Boulevard, Québec (Québec), G1V 4G2, Canada.

Med Chem ; 7(2): 80-91, 2011 Mar.

Article in En | MEDLINE | ID: mdl-21222612

Subject(s)

Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Estradiol Dehydrogenases/antagonists & inhibitors; Estradiol/chemistry; Furans/chemistry; Enzyme Inhibitors/chemistry; Estradiol/chemical synthesis; Estradiol/pharmacology; Estradiol Dehydrogenases/metabolism; Furans/chemical synthesis; Furans/pharmacology; Humans; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Estradiol / Estradiol Dehydrogenases / Furans Limits: Humans Language: En Journal: Med Chem Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: Canada

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