HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer.

Spraggs, Colin F; Budde, Laura R; Briley, Linda P; Bing, Nan; Cox, Charles J; King, Karen S; Whittaker, John C; Mooser, Vincent E; Preston, Alaknanda J; Stein, Steven H; Cardon, Lon R

Spraggs, Colin F; Budde, Laura R; Briley, Linda P; Bing, Nan; Cox, Charles J; King, Karen S; Whittaker, John C; Mooser, Vincent E; Preston, Alaknanda J; Stein, Steven H; Cardon, Lon R.

Affiliation

Spraggs CF; GlaxoSmithKline Research and Development, Genetics Division, Medicines Development Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NF, United Kingdom. colin.f.spraggs@gsk.com

J Clin Oncol ; 29(6): 667-73, 2011 Feb 20.

Article in En | MEDLINE | ID: mdl-21245432

Subject(s)

Antineoplastic Agents/adverse effects; Breast Neoplasms/genetics; Genetic Predisposition to Disease/genetics; HLA-DQ Antigens/genetics; Liver Diseases/etiology; Quinazolines/adverse effects; Aged; Alanine Transaminase/blood; Breast Neoplasms/drug therapy; Breast Neoplasms/pathology; Case-Control Studies; Female; Genotype; HLA-DQ alpha-Chains; Humans; Lapatinib; Liver/drug effects; Liver Function Tests; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Breast Neoplasms / HLA-DQ Antigens / Genetic Predisposition to Disease / Liver Diseases / Antineoplastic Agents Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Middle aged Language: En Journal: J Clin Oncol Year: 2011 Type: Article Affiliation country: United kingdom

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