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Chromosomal aberrations in chronic lymphocytic leukemia detected by conventional cytogenetics with DSP30 as a single agent: comparison with FISH.
Kotkowska, Aleksandra; Wawrzyniak, Ewa; Blonski, Jerzy Z; Robak, Tadeusz; Korycka-Wolowiec, Anna.
Affiliation
  • Kotkowska A; Copernicus Memorial Hospital, Lodz, Poland.
Leuk Res ; 35(8): 1032-8, 2011 Aug.
Article in En | MEDLINE | ID: mdl-21333354
ABSTRACT
The aim of our study was to estimate the usefulness for conventional cytogenetics (CC) of DSP30 as a single agent (CC-DSP30) for detecting the most important chromosomal aberrations revealed in CLL by FISH and to find other abnormalities possibly existing but undetected by FISH with standard probes. Using CC-DSP30, the metaphases suitable for analysis were obtained in 90% of patients. CC-DSP30 and FISH were similarly efficacious for detecting del(11)(q22) and trisomy 12, whereas FISH was more sensitive for del(13)(q14). Sole del(13)(q14) detected by FISH, in 50% of patients was associated with other aberrations revealed by CC-DSP30. Additionally, the most recurrent anomaly detected by CC-DSP30 were structural aberrations of chromosome 2.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Leukemia, Lymphocytic, Chronic, B-Cell / Chromosome Aberrations / In Situ Hybridization, Fluorescence Type of study: Prognostic_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Leuk Res Year: 2011 Type: Article Affiliation country: Poland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Leukemia, Lymphocytic, Chronic, B-Cell / Chromosome Aberrations / In Situ Hybridization, Fluorescence Type of study: Prognostic_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Leuk Res Year: 2011 Type: Article Affiliation country: Poland