A selective phosphodiesterase-4 inhibitor reduces leukocyte infiltration, oxidative processes, and tissue damage after spinal cord injury.

Bao, Feng; Fleming, Jennifer C; Golshani, Roozbeh; Pearse, Damien D; Kasabov, Levent; Brown, Arthur; Weaver, Lynne C

Bao, Feng; Fleming, Jennifer C; Golshani, Roozbeh; Pearse, Damien D; Kasabov, Levent; Brown, Arthur; Weaver, Lynne C.

Affiliation

Bao F; Spinal Cord Injury Team, Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada. fbao@uwo.ca

J Neurotrauma ; 28(6): 1035-49, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21355819

Subject(s)

Chemotaxis, Leukocyte/drug effects; Nerve Degeneration/prevention & control; Neuroprotective Agents/pharmacology; Oxidative Stress/drug effects; Phosphodiesterase 4 Inhibitors/pharmacology; Spinal Cord Injuries/drug therapy; Animals; Chemotaxis, Leukocyte/physiology; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism; Disease Models, Animal; Female; Male; Myelitis/drug therapy; Myelitis/enzymology; Myelitis/pathology; Nerve Degeneration/enzymology; Nerve Degeneration/pathology; Oxidative Stress/physiology; Phosphodiesterase 4 Inhibitors/therapeutic use; Rats; Rats, Wistar; Spinal Cord Injuries/enzymology; Spinal Cord Injuries/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Injuries / Chemotaxis, Leukocyte / Oxidative Stress / Neuroprotective Agents / Phosphodiesterase 4 Inhibitors / Nerve Degeneration Limits: Animals Language: En Journal: J Neurotrauma Journal subject: NEUROLOGIA / TRAUMATOLOGIA Year: 2011 Type: Article Affiliation country: Canada

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