Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis.

Llorente Izquierdo, Cristina; Mayoral, Rafael; Flores, Juana María; García-Palencia, Pilar; Cucarella, Carme; Boscá, Lisardo; Casado, Marta; Martín-Sanz, Paloma

Llorente Izquierdo, Cristina; Mayoral, Rafael; Flores, Juana María; García-Palencia, Pilar; Cucarella, Carme; Boscá, Lisardo; Casado, Marta; Martín-Sanz, Paloma.

Affiliation

Llorente Izquierdo C; Institute of Biomedical Research Alberto Sols (CSIC-UAM), Madrid, Spain.

Am J Pathol ; 178(3): 1361-73, 2011 Mar.

Article in En | MEDLINE | ID: mdl-21356386

Subject(s)

Cyclooxygenase 2/metabolism; Hepatocytes/enzymology; Liver Neoplasms/enzymology; Liver Neoplasms/pathology; Precancerous Conditions/enzymology; Precancerous Conditions/pathology; Aging/pathology; Animals; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/pathology; Cyclin E/metabolism; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Hepatitis/complications; Hepatitis/pathology; Hepatocytes/pathology; Humans; Liver/metabolism; Liver/pathology; Liver Cirrhosis/complications; Liver Cirrhosis/enzymology; Liver Cirrhosis/pathology; Liver Neoplasms/genetics; Mice; Mice, Nude; Mice, Transgenic; Organ Size; Precancerous Conditions/chemically induced; Proto-Oncogene Proteins c-myc/metabolism; Transgenes/genetics; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precancerous Conditions / Hepatocytes / Cyclooxygenase 2 / Liver Neoplasms Limits: Animals / Humans Language: En Journal: Am J Pathol Year: 2011 Type: Article Affiliation country: Spain

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