The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.

Di Meglio, Paola; Di Cesare, Antonella; Laggner, Ute; Chu, Chung-Ching; Napolitano, Luca; Villanova, Federica; Tosi, Isabella; Capon, Francesca; Trembath, Richard C; Peris, Ketty; Nestle, Frank O

Di Meglio, Paola; Di Cesare, Antonella; Laggner, Ute; Chu, Chung-Ching; Napolitano, Luca; Villanova, Federica; Tosi, Isabella; Capon, Francesca; Trembath, Richard C; Peris, Ketty; Nestle, Frank O.

Affiliation

Di Meglio P; St John's Institute of Dermatology, King's College London and NIHR Biomedical Research Centre, London, United Kingdom.

PLoS One ; 6(2): e17160, 2011 Feb 22.

Article in En | MEDLINE | ID: mdl-21364948

Subject(s)

Immune System Diseases/genetics; Immunity, Cellular/genetics; Interleukin-23/pharmacology; Lymphocyte Activation/drug effects; Receptors, Interleukin/genetics; Th17 Cells/drug effects; Adult; Aged; Amino Acid Substitution/genetics; Amino Acid Substitution/physiology; Arginine/genetics; Cell Differentiation/genetics; Cell Differentiation/immunology; Cells, Cultured; Cytoprotection/drug effects; Cytoprotection/genetics; Down-Regulation/genetics; Down-Regulation/immunology; Female; Glutamic Acid/genetics; Humans; Immunity, Cellular/drug effects; Interleukin-23/metabolism; Lymphocyte Activation/genetics; Male; Middle Aged; Mutation, Missense/physiology; Polymorphism, Single Nucleotide/physiology; Receptors, Interleukin/physiology; Th17 Cells/immunology; Th17 Cells/physiology; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / Receptors, Interleukin / Interleukin-23 / Th17 Cells / Immunity, Cellular / Immune System Diseases Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Type: Article Affiliation country: United kingdom

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