Polycythemia in an infant secondary to granulocyte transfusions.
Pediatr Blood Cancer
; 57(7): 1236-8, 2011 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-21370438
ABSTRACT
Granulocyte transfusions may be useful for neutropenic pediatric patients with refractory bacterial or fungal infections. Many potential adverse sequelae associated with granulocyte transfusions are well recognized, including febrile reactions, fluid overload, alloimmunization, and lung injury. Other potential adverse sequelae, however, are less well known. This case report describes an infant with familial hemophagocytic lymphohistiocytosis who developed polycythemia (hemoglobin 10-17.6 g/dl) following four daily transfusions of 20 ml/kg of apheresis collected, steroid stimulated donor granulocytes. Expanded knowledge of potential risks of transfused granulocytes will allow for rapid recognition of transfusion-related complications, should they occur.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polycythemia
/
Leukocyte Transfusion
/
Lymphohistiocytosis, Hemophagocytic
/
Granulocytes
Type of study:
Etiology_studies
Limits:
Female
/
Humans
/
Infant
Language:
En
Journal:
Pediatr Blood Cancer
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Year:
2011
Type:
Article
Affiliation country:
United States