Use of the NEO strategy (Nucleophilic addition/Epoxide Opening) for the synthesis of a new C-galactoside ester analogue of KRN 7000.
Bioorg Med Chem Lett
; 21(8): 2510-4, 2011 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-21392982
ABSTRACT
Our goal in the search for potentially bioactive analogues of KRN 7000 was to design an easy synthetic approach to a library of analogues using a strategy recently developed in our laboratory based on a Nucleophilic addition followed by an Epoxide Opening (the NEO strategy). Through the use of a common pivotal structure, a new C-galactoside ester analogue (23) was synthesized which showed an encouraging T(H)2 biased response during preliminary biological tests.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glycolipids
/
Galactosides
/
Galactosylceramides
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2011
Type:
Article
Affiliation country:
France