Cocaine withdrawal impairs metabotropic glutamate receptor-dependent long-term depression in the nucleus accumbens.

Huang, Chiung-Chun; Yeh, Che-Ming; Wu, Mei-Ying; Chang, Alice Y W; Chan, Julie Y H; Chan, Samuel H H; Hsu, Kuei-Sen

Huang, Chiung-Chun; Yeh, Che-Ming; Wu, Mei-Ying; Chang, Alice Y W; Chan, Julie Y H; Chan, Samuel H H; Hsu, Kuei-Sen.

Affiliation

Huang CC; Department of Pharmacology, and Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City 701, Republic of China.

J Neurosci ; 31(11): 4194-203, 2011 Mar 16.

Article in En | MEDLINE | ID: mdl-21411660

Subject(s)

Cocaine-Related Disorders/physiopathology; Cocaine/adverse effects; Long-Term Synaptic Depression/drug effects; Nucleus Accumbens/drug effects; Receptors, Metabotropic Glutamate/metabolism; Substance Withdrawal Syndrome/physiopathology; Analysis of Variance; Animals; Blotting, Western; Brain-Derived Neurotrophic Factor/metabolism; Electrophysiology; Enzyme-Linked Immunosorbent Assay; Long-Term Synaptic Depression/physiology; Male; Mice; Motor Activity/drug effects; Motor Activity/physiology; Nucleus Accumbens/physiopathology; Receptors, Metabotropic Glutamate/agonists; Receptors, Metabotropic Glutamate/antagonists & inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Synaptic Transmission/drug effects; Synaptic Transmission/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Substance Withdrawal Syndrome / Cocaine / Receptors, Metabotropic Glutamate / Cocaine-Related Disorders / Long-Term Synaptic Depression / Nucleus Accumbens Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Year: 2011 Type: Article Affiliation country: China

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