Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3.

Ghaffari, Amir A; Chow, Edward K; Iyer, Shankar S; Deng, Jane C; Cheng, Genhong

Ghaffari, Amir A; Chow, Edward K; Iyer, Shankar S; Deng, Jane C; Cheng, Genhong.

Affiliation

Ghaffari AA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.

Hepatology ; 53(6): 2042-52, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21433044

Subject(s)

Acetaminophen/adverse effects; Antiviral Agents/therapeutic use; Chemical and Drug Induced Liver Injury/metabolism; Chemical and Drug Induced Liver Injury/prevention & control; Interferon Type I/metabolism; Poly I-C/therapeutic use; Toll-Like Receptor 3/metabolism; Acetaminophen/metabolism; Animals; Antiviral Agents/pharmacology; Cytochrome P-450 Enzyme System/metabolism; Drug Synergism; Liver/drug effects; Liver/metabolism; Male; Mice; Poly I-C/pharmacology; Pregnane X Receptor; RNA, Double-Stranded/pharmacology; RNA, Viral/genetics; Receptors, Steroid/metabolism; Retinoid X Receptor alpha/metabolism; Xenobiotics/pharmacology; Xenobiotics/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Interferon Type I / Poly I-C / Toll-Like Receptor 3 / Chemical and Drug Induced Liver Injury / Acetaminophen Limits: Animals Language: En Journal: Hepatology Year: 2011 Type: Article Affiliation country: United States

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