Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans.

Nesterovitch, Andrew B; Szanto, Sandor; Gonda, Andrea; Bardos, Tamas; Kis-Toth, Katalin; Adarichev, Vyacheslav A; Olasz, Katalin; Ghassemi-Najad, Sheida; Hoffman, Mark D; Tharp, Michael D; Mikecz, Katalin; Glant, Tibor T

Nesterovitch, Andrew B; Szanto, Sandor; Gonda, Andrea; Bardos, Tamas; Kis-Toth, Katalin; Adarichev, Vyacheslav A; Olasz, Katalin; Ghassemi-Najad, Sheida; Hoffman, Mark D; Tharp, Michael D; Mikecz, Katalin; Glant, Tibor T.

Affiliation

Nesterovitch AB; Department of Dermatology, Rush University Medical Center, Chicago, Illinois, USA.

Am J Pathol ; 178(4): 1701-14, 2011 Apr.

Article in En | MEDLINE | ID: mdl-21435452

Subject(s)

Hereditary Autoinflammatory Diseases/genetics; Neutrophils/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 6/genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 6/physiology; Skin Diseases/metabolism; Adrenal Cortex Hormones/pharmacology; Animals; Autoantibodies/chemistry; Chromosome Mapping; Homozygote; Humans; Immunoglobulins/chemistry; Inflammation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Diseases / Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Hereditary Autoinflammatory Diseases / Neutrophils Limits: Animals / Humans Language: En Journal: Am J Pathol Year: 2011 Type: Article Affiliation country: United States

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