The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.

Flick, Matthew J; Chauhan, Anil K; Frederick, Malinda; Talmage, Kathryn E; Kombrinck, Keith W; Miller, Whitney; Mullins, Eric S; Palumbo, Joseph S; Zheng, Xunzhen; Esmon, Naomi L; Esmon, Charles T; Thornton, Sherry; Becker, Ann; Pelc, Leslie A; Di Cera, Enrico; Wagner, Denisa D; Degen, Jay L

Flick, Matthew J; Chauhan, Anil K; Frederick, Malinda; Talmage, Kathryn E; Kombrinck, Keith W; Miller, Whitney; Mullins, Eric S; Palumbo, Joseph S; Zheng, Xunzhen; Esmon, Naomi L; Esmon, Charles T; Thornton, Sherry; Becker, Ann; Pelc, Leslie A; Di Cera, Enrico; Wagner, Denisa D; Degen, Jay L.

Affiliation

Flick MJ; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Blood ; 117(23): 6326-37, 2011 Jun 09.

Article in En | MEDLINE | ID: mdl-21436072

Subject(s)

Arthritis, Experimental/metabolism; Mutation, Missense; Prothrombin/metabolism; Amino Acid Substitution; Animals; Arthritis, Experimental/genetics; Hemorrhage/genetics; Hemorrhage/metabolism; Humans; Mice; Mice, Mutant Strains; Protein C/genetics; Protein C/metabolism; Prothrombin/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Prothrombin / Mutation, Missense Limits: Animals / Humans Language: En Journal: Blood Year: 2011 Type: Article Affiliation country: United States

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