Lung function response to bronchodilator nebulization via hood in wheezy infants: a pilot study.
Isr Med Assoc J
; 13(1): 39-43, 2011 Jan.
Article
in En
| MEDLINE
| ID: mdl-21446235
ABSTRACT
BACKGROUND:
In infants, small volume nebulizers with a face mask are commonly used to facilitate aerosol therapy. However, infants may be disturbed by mask application, causing poor mask-to-face seal and thus reducing the dose delivered.OBJECTIVES:
To compare lung function response to bronchodilator nebulization via two delivery devices hood versus mask.METHODS:
We studied 26 recurrently wheezy infants aged 45.8 weeks (95% confidence interval 39.6-52.0). Inhalations of 0.30 mg/kg salbutamol were administered in two alliqots 30 minutes apart using mask and hood in alternating order (M+H or H+M). Response to inhalations was measured by maximal expiratory flows at functional residual capacity (V'maxFRC) at 5 minute intervals after each dose, and area under the V'maxFRC curve (AUC) was documented.RESULTS:
A small but significant response to salbutamol was observed following the second inhalation with V'maxFRC, improving by 31.7% (7.2-56.2, P (0.02) and AUC by 425% x min (-154, 1004; P < 0.02). The improvement following salbutamol was similar by both delivery modalities but with a small but significantly better response when H was used after M (P < 0.01).CONCLUSIONS:
Nebulized salbutamol induced a variable but positive response in wheezy infants. Salbutamol via hood was as effective as conventional face mask delivery. Since it is simple and patient-friendly, it could replace the face mask method particularly with uncooperative infants.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Nebulizers and Vaporizers
/
Bronchodilator Agents
/
Albuterol
/
Masks
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Isr Med Assoc J
Journal subject:
MEDICINA
Year:
2011
Type:
Article
Affiliation country:
Israel