Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.

Meduna, Steven P; Savall, Brad M; Cai, Hui; Edwards, James P; Thurmond, Robin L; McGovern, Patricia M

Meduna, Steven P; Savall, Brad M; Cai, Hui; Edwards, James P; Thurmond, Robin L; McGovern, Patricia M.

Affiliation

Meduna SP; Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. smeduna@its.jnj.com

Bioorg Med Chem Lett ; 21(10): 3113-6, 2011 May 15.

Article in En | MEDLINE | ID: mdl-21458260

Subject(s)

Pyridines/pharmacology; Pyrimidines/pharmacology; Receptors, G-Protein-Coupled/antagonists & inhibitors; Amines/chemistry; Binding, Competitive; Biological Assay; Humans; Inhibitory Concentration 50; Molecular Structure; Protein Binding/drug effects; Pyridines/chemical synthesis; Pyridines/chemistry; Pyrimidines/chemical synthesis; Pyrimidines/chemistry; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / Receptors, G-Protein-Coupled Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: United States

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