Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension.

Vergadi, Eleni; Chang, Mun Seog; Lee, Changjin; Liang, Olin D; Liu, Xianlan; Fernandez-Gonzalez, Angeles; Mitsialis, S Alex; Kourembanas, Stella

Vergadi, Eleni; Chang, Mun Seog; Lee, Changjin; Liang, Olin D; Liu, Xianlan; Fernandez-Gonzalez, Angeles; Mitsialis, S Alex; Kourembanas, Stella.

Affiliation

Vergadi E; Division of Newborn Medicine, Children's Hospital Boston, Harvard Medical School, MA 02115, USA.

Circulation ; 123(18): 1986-95, 2011 May 10.

Article in En | MEDLINE | ID: mdl-21518986

Subject(s)

Heme Oxygenase-1/immunology; Hypertension, Pulmonary/immunology; Hypoxia/immunology; Macrophage Activation/immunology; Macrophages, Alveolar/immunology; Animals; Carbon Dioxide/metabolism; Cell Division/immunology; Heme Oxygenase-1/genetics; Heme Oxygenase-1/metabolism; Humans; Hypertension, Pulmonary/pathology; Hypoxia/pathology; Interleukin-10/metabolism; Macrophages, Alveolar/pathology; Mice; Mice, Transgenic; Monocytes/immunology; Monocytes/pathology; Muscle, Smooth, Vascular/immunology; Muscle, Smooth, Vascular/pathology; Pneumonia/immunology; Pneumonia/pathology; Pulmonary Artery/immunology; Pulmonary Artery/pathology; Transcriptional Activation/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macrophages, Alveolar / Heme Oxygenase-1 / Hypertension, Pulmonary / Macrophage Activation / Hypoxia Limits: Animals / Humans Language: En Journal: Circulation Year: 2011 Type: Article Affiliation country: United States

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