Endothelin-1 signaling promotes fibrosis in vitro in a bronchopulmonary dysplasia model by activating the extrinsic coagulation cascade.

Kambas, Konstantinos; Chrysanthopoulou, Akrivi; Kourtzelis, Ioannis; Skordala, Marianna; Mitroulis, Ioannis; Rafail, Stavros; Vradelis, Stergios; Sigalas, Ioannis; Wu, You-Qiang; Speletas, Matthaios; Kolios, George; Ritis, Konstantinos

Kambas, Konstantinos; Chrysanthopoulou, Akrivi; Kourtzelis, Ioannis; Skordala, Marianna; Mitroulis, Ioannis; Rafail, Stavros; Vradelis, Stergios; Sigalas, Ioannis; Wu, You-Qiang; Speletas, Matthaios; Kolios, George; Ritis, Konstantinos.

Affiliation

Kambas K; First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis 68100, Greece.

J Immunol ; 186(11): 6568-75, 2011 Jun 01.

Article in En | MEDLINE | ID: mdl-21531894

Subject(s)

Bronchopulmonary Dysplasia/metabolism; Endothelin-1/metabolism; Respiratory Distress Syndrome, Newborn/metabolism; Signal Transduction; Blotting, Western; Bronchoalveolar Lavage Fluid/chemistry; Bronchopulmonary Dysplasia/genetics; Bronchopulmonary Dysplasia/pathology; Cells, Cultured; Colon/metabolism; Colon/pathology; Complement C5a/genetics; Complement C5a/metabolism; Connective Tissue Growth Factor/genetics; Connective Tissue Growth Factor/metabolism; Endothelin-1/genetics; Female; Fibrosis; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Humans; Immunohistochemistry; Infant, Newborn; Lung/metabolism; Lung/pathology; Male; Microscopy, Fluorescence; Myofibroblasts/metabolism; Myofibroblasts/pathology; Receptor, Anaphylatoxin C5a; Receptor, PAR-1/genetics; Receptor, PAR-1/metabolism; Receptors, Complement/genetics; Receptors, Complement/metabolism; Respiratory Distress Syndrome, Newborn/genetics; Respiratory Distress Syndrome, Newborn/pathology; Reverse Transcriptase Polymerase Chain Reaction; Thrombin/genetics; Thrombin/metabolism; Thromboplastin/genetics; Thromboplastin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Distress Syndrome, Newborn / Bronchopulmonary Dysplasia / Signal Transduction / Endothelin-1 Type of study: Prognostic_studies Language: En Journal: J Immunol Year: 2011 Type: Article Affiliation country: Greece

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