Interleukin 10 and residual kidney function are associated with risk of vascular calcification in patients undergoing peritoneal dialysis.
Clin Nephrol
; 75(5): 397-402, 2011 May.
Article
in En
| MEDLINE
| ID: mdl-21543018
ABSTRACT
AIMS:
Vascular calcification is a common complication among dialysis patients and its pathogenesis involves a variety of factors. The roles of pro-inflammatory cytokines and residual kidney function (RKF) in peritoneal dialysis (PD) patients with vascular calcification have not been investigated. MATERIALS ANDMETHODS:
157 stable PD patients were enrolled. All patients had plain X-ray film examination including chest (posterior-anterior view, CXR) and pelvis. Vascular calcification was interpreted as calcified deposit over aortic arch and linear calcification of pelvic arteries. Relevant biochemical data, pro-inflammatory markers, and PD-related factors were measured and collected.RESULTS:
Vascular calcification prevalence in CXRs was higher than that in pelvis films (38.2% vs. 22.3%, p < 0.05). Patients with vascular calcification in CXR had higher incidence of calcification in pelvis films (p < 0.05). Only a minor portion (14.6%) had two calcification sites. Regression analysis revealed that age, PD duration, body mass index, and RKF were independent factors associated with vascular calcification in CXR. Age, diabetes, IL-10 and RKF were factors associated in pelvis films. Factors independently related to vascular calcification in both films were age, duration, diabetes, IL-10, and RKF.CONCLUSIONS:
Besides traditional risk factors, IL-10 and RKF were important factors associated with vascular calcification in PD patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vascular Diseases
/
Calcinosis
/
Peritoneal Dialysis
/
Interleukin-10
/
Kidney
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Nephrol
Year:
2011
Type:
Article
Affiliation country:
Taiwan