Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.

Lebon, Guillaume; Warne, Tony; Edwards, Patricia C; Bennett, Kirstie; Langmead, Christopher J; Leslie, Andrew G W; Tate, Christopher G

Lebon, Guillaume; Warne, Tony; Edwards, Patricia C; Bennett, Kirstie; Langmead, Christopher J; Leslie, Andrew G W; Tate, Christopher G.

Affiliation

Lebon G; MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

Nature ; 474(7352): 521-5, 2011 May 18.

Article in En | MEDLINE | ID: mdl-21593763

Subject(s)

Adenosine A2 Receptor Agonists/metabolism; Receptor, Adenosine A2A/chemistry; Receptor, Adenosine A2A/metabolism; Adenosine/chemistry; Adenosine/metabolism; Adenosine/pharmacology; Adenosine A2 Receptor Agonists/pharmacology; Adenosine-5'-(N-ethylcarboxamide)/chemistry; Adenosine-5'-(N-ethylcarboxamide)/metabolism; Adenosine-5'-(N-ethylcarboxamide)/pharmacology; Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Drug Inverse Agonism; Humans; Ligands; Models, Molecular; Molecular Conformation; Triazines/metabolism; Triazines/pharmacology; Triazoles/metabolism; Triazoles/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Adenosine A2A / Adenosine A2 Receptor Agonists Limits: Animals / Humans Language: En Journal: Nature Year: 2011 Type: Article Affiliation country: United kingdom

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