Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest.
Cell Mol Life Sci
; 68(15): 2493-8, 2011 Aug.
Article
in En
| MEDLINE
| ID: mdl-21598020
ABSTRACT
Alpha-T-Catenin (CTNNA3) is a key protein of the adherens junctional complex in epithelial cells playing a crucial role in cellular adherence. What makes this gene particularly interesting is that it is located within a common fragile site, is epigenetically regulated, is transcribed through multiple promoters, and generates a variety of alternate transcripts. Finally, CTNNA3 has a nested gene (LRTMM3) embedded within its genomic context transcribed in the opposite direction. Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nested Genes
/
Alpha Catenin
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Mol Life Sci
Journal subject:
BIOLOGIA MOLECULAR
Year:
2011
Type:
Article
Affiliation country:
Ireland