The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization.

Puglisi, Rossella; Maccari, Irene; Pipolo, Simona; Conrad, Marcus; Mangia, Franco; Boitani, Carla

Puglisi, Rossella; Maccari, Irene; Pipolo, Simona; Conrad, Marcus; Mangia, Franco; Boitani, Carla.

Affiliation

Puglisi R; DAHFMO, Section of Histology & Medical Embryology, University of Rome La Sapienza, Rome, Italy.

J Cell Physiol ; 227(4): 1420-7, 2012 Apr.

Article in En | MEDLINE | ID: mdl-21618532

Subject(s)

Chromatin Assembly and Disassembly/physiology; Fertilization/physiology; Glutathione Peroxidase/metabolism; Spermatozoa/enzymology; Animals; COS Cells; Chlorocebus aethiops; Chromosomal Instability/physiology; Embryonic Development/physiology; Epididymis/cytology; Epididymis/enzymology; Female; Fertilization in Vitro; Glutathione Peroxidase/deficiency; Glutathione Peroxidase/genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Matrix/enzymology; Oocytes/physiology; Phospholipid Hydroperoxide Glutathione Peroxidase; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Spermatogenesis/physiology; Spermatozoa/physiology; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermatozoa / Chromatin Assembly and Disassembly / Fertilization / Glutathione Peroxidase Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Cell Physiol Year: 2012 Type: Article Affiliation country: Italy

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